Comparison of aspirin combined with low molecular weight heparin versus aspirin alone for habitual abortion: a systematic review and meta-analysis of randomized controlled trials
نویسندگان
چکیده
Background: The efficacy of aspirin combined with low molecular weight heparin in the treatment of habitual abortion is controversial. The efficacy of aspirin combined with low molecular weight heparin versus aspirin alone for habitual abortion is still unclear. Aim: The purpose is to compare the efficacy of low molecular weight heparin therapy versus aspirin monotherapy for habitual abortion. Methods: The PubMed, EMBASE, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biology Medicine (CBM), VIP database and Wanfang database were searched to identify randomized controlled trials (RCTs) about aspirin combined with low molecular weight heparin in the treatment of habitual abortion without date or language restrictions (last search up to April, 2016) and reference lists of relevant reviews were checked to identify additional studies. We calculated relative risk (RR) with 95% confidence interval (CI) using Stata 14.0 software. Results: The results of meta-analysis suggested that combination therapy improved the live birth rate [RR, 1.18, 95% CI, (1.06, 1.31), I2=0%, P=0.002] and significantly reduced abortion rate [RR, 0.55, 95% CI, (0.44, 0.69), I2=2.1%, P=0.000] compared with aspirin monotherapy. Conclusion: Combination therapy shows benefic effects in the treatment of women with habitual abortion and is better than aspirin alone therapy. Further study is required to confirm these findings.
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